The leakage of the acoustic energy from the substrate into the drop drives bulk internal fluid recirculation within the drop, known as acoustic streaming. Through symmetry breaking, it is possible to cause the liquid to swirl circumferentially, thus generating a centrifugation action. We have demonstrated that this gives rise to a strong inertial-dominant microcentrifugation effect, which can be exploited for intense micromixing or fast particle concentration/separation. Indeed, it has been shown that chemical and biochemical reaction kinetics can be enhanced significantly when subject to the intense microcentrifugal mixing flows under surface acoustic wave excitation. In addition, we show the possibility of spinning tiny discs on which microchannels and other microfluidic structures can be patterned. Unlike its macroscopic Lab-on-a-CD counterpart, the miniaturised Lab-on-a-Disc (miniLOAD) platform does not require moving parts, is inexpensive, disposable, and significantly smaller both in terms of the disc itself and the portable palmtop battery-operated circuit used to power the chip-sized device. To the best of our knowledge, the miniLOAD concept is the first microcentrifugation platform small enough to comprise a handheld device.